Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances

doi:10.5306/wjco.v13.i6.448

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World Journal of Clinical Oncology

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World J Clin Oncol. Jun 24, 2022; 13(6): 448-472
Published online Jun 24, 2022. doi: 10.5306/wjco.v13.i6.448

Table 1 Ongoing clinical trials investigating immune checkpoint inhibitor - oral tyrosine kinase inhibitor combinations

NCT	Phase	Study drugs	Treatment line	Endpoint	Estimated End of Trial
NCT04194775	3	CS1003 +LENVATINIB vs LENVATINIB	1	OS, PFS	June 2023
NCT04344158	3	PENPULIMAB + ANLOTINIB vs SORAFENIB	1	OS	December 2024
NCT03713593	3	PEMBROLIZUMAB + LENVATINIB vs LENVATINIB	1	OS, PFS	May 2022
NCT04411706	2	SINTILIMAB + APATINIB + CAPECITABINE	1	ORR	June 2022
NCT04042805	2	SINTILIMAB + LENVATINIB	1	ORR	August 2024
NCT04444167	2	BISPECIFIC AK104 + LENVATINIB	1	ORR	March 2022
NCT04183088	2	TISLELIZUMAB + REGORAFENIB	1	ORR, PFS, Safety	March 2025
NCT04310709	2	NIVOLUMAB + REGORAFENIB	1	ORR	May 2023
NCT04442581	2	PEMBROLIZUMAB + CABOZANTINIB	1	ORR	September 2024
NCT03439891	2	NIVOLUMAB + SORAFENIB	1	MTD, ORR	May 2022
NCT04170556	2	NIVOLUMAB + REGORAFENIB	2	Safety	December 2022
NCT04401800	1b/2	TISLELIZUMAB + LENVATINIB	1	ORR	December 2022
NCT04443309	1b/2	CAMRELIZUMAB + LENVATINIB	1	ORR	August 2024
NCT03347292	1	PEMBROLIZUMAB + REGORAFENIB	1	DLT, Safety	October 2022

NCT: Number of the clinical trial (Clinicaltrials.gov); OS: Overall survival; PFS: Progression-free survival; ORR: Overall response rate; MTD: Maximum tolerated dose; DLT: Dose-limiting toxicities.

Citation: Rallis KS, Makrakis D, Ziogas IA, Tsoulfas G. Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances. World J Clin Oncol 2022; 13(6): 448-472
URL: https://www.wjgnet.com/2218-4333/full/v13/i6/448.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i6.448