New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2

doi:10.5306/wjco.v13.i4.276

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Apr 24, 2022; 13(4): 276-286
Published online Apr 24, 2022. doi: 10.5306/wjco.v13.i4.276

Table 4 Clinical trials of mesenchymal-epithelial transition factor inhibitors

Drug	Clinical trial	Phase	Treatment	Objective	Status
Glesatinib	NCT02954991	2	Glesatinib + Nivolumab	ORR	Active, not recruiting
Multi-TKI	NCT02954991	2	Glesatinib + Nivolumab	ORR	Active, not recruiting
Glesatinib	NCT02544633	2	Glesatinib	ORR	Completed
Multi-TKI	NCT02544633	2	Glesatinib	ORR	Completed
Merestinib	NCT02920996	2	Merestinib	ORR	Active, not recruiting
Multi-TKI	NCT02920996	2	Merestinib	ORR	Active, not recruiting
Savolitinib	NCT02897479	2	Savolitinib	ORR	Active, not recruiting
Selective-TKI	NCT02897479	2	Savolitinib	ORR	Active, not recruiting
Telisotuzumab (ABBV 399)	NCT03574753	2	ABBV-399	ORR	Completed
MET-mab	NCT03574753	2	ABBV-399	ORR	Completed
JNJ-61186372	NCT02609776	1	JNJ-61186372	ORR, security	Recruiting
EGFR and MET mab	NCT02609776	1	JNJ-61186372	ORR, security	Recruiting

TKI: Tyrosine kinase inhibitor; mab: Monoclonal antibody; ORR: Overall response rate; MET: Mesenchymal-epithelial transition factor; EGFR: Epidermal growth factor receptor.

Citation: Olmedo ME, Cervera R, Cabezon-Gutierrez L, Lage Y, Corral de la Fuente E, Gómez Rueda A, Mielgo-Rubio X, Trujillo JC, Couñago F. New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2. World J Clin Oncol 2022; 13(4): 276-286
URL: https://www.wjgnet.com/2218-4333/full/v13/i4/276.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i4.276