New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2

doi:10.5306/wjco.v13.i4.276

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Apr 24, 2022 (publication date) through Nov 22, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Apr 24, 2022; 13(4): 276-286
Published online Apr 24, 2022. doi: 10.5306/wjco.v13.i4.276

Table 1 Phase II trials with BRAF inhibitors

Drug	n	ORR (%)	PFS (mo)	OS (mo)
Vemurafenib BRAF V600E[8]	62	37.1	6.51	15.38
Vemurafenib V600E[9]	101	0	5.2	10
Vemurafenib non-V600E[9]	17	44.9	NR	NR
Dabrafenib in 2^nd line or beyond[10]	78	33.3	5.5	12.7
Dabrafenib + trametinib in 2^nd line or beyond[11]	57	63.2	10.2	18.2
Dabrafenib + trametinib en 1^st line[12]	36	64	10.9	24.6

ORR: Overall response rate; PFS: Progression free survival; OS: Overall survival; NR: Not reported.

Citation: Olmedo ME, Cervera R, Cabezon-Gutierrez L, Lage Y, Corral de la Fuente E, Gómez Rueda A, Mielgo-Rubio X, Trujillo JC, Couñago F. New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2. World J Clin Oncol 2022; 13(4): 276-286
URL: https://www.wjgnet.com/2218-4333/full/v13/i4/276.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i4.276