Tsunami of immunotherapy reaches mesothelioma

Table 1 Main pre-phase III clinical trials of immunotherapy-based strategies for the treatment of mesothelioma

Clinical trial (Phase): Drug analyzed	Setting	Primary endpoint
MESOT-TREM 2008 (Phase II): Tremelimumab 15 mg/kg every 90 d[23]	Salvage setting	ORR: 6.9%
MESOT-TREM 2012 (Phase II): Tremelimumab 10 mg/kg every 4 wk[24]	Salvage setting	ORR: 13.7%
DETERMINE (Phase IIb): Tremelimumab 10 mg/kg every 4 wk vs Placebo[25]	Salvage setting	OS: 7.7 mo vs 7.3 mo (HR = 0.92; P = 0.41)
DREAM (Phase II): Durvalumab 1125 mg + Cisplatin 75 mg/m2 or Carboplatin AUC 5 + Pemexetrad 500 mg/m2 every 3 wk[26]	Front-line setting	6-mo PFS: 57%
JAVELIN Solid (Phase Ib): Avelumab 10 mg/kg every 2 wk[27]	Salvage setting	ORR: 9%

AEs: Adverse events; AUC 5: Area under the curve value of 5; HR: Hazard ratio; ORR: Overall response rate; OS: Overall survival; PFS: Progression free survival.