GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer

Table 8 Dose constraints for moderate hypofractionation

Organ	Concurrent RT/ChT (55 Gy/20 fx)	Sequential RT/ChT (55 Gy/20 fx)	RT (50-58 Gy/15 fx)	RT (50-60 Gy/15 fx)[138]
Spinal cord	MD 44 Gy (0.1 cc)	Dmax ≤ 36	MD 42 Gy (0.1 cc)	MD < 38 Gy
Esophagus1	MD < 55 Gy (1 cc)	V42 < 32%	MD < 52 Gy (1 cc)	MD < 50 Gy (1 cc), V45 < 10 cc
Lungs-GTV	V20 < 35%, MD < 18 Gy	V20 < 25%-30%, MD ≤ 15 Gy	V19 < 35%, MD < 16 Gy	V20 < 30%, V5 < 60%, MD < 20 Gy
Heart	V30 < 36%	V33 < 25%	D100% < 33 Gy, D67% < 40 Gy, D33% < 52 Gy	MD 63 Gy, V57 < 10 cc
Great vessels	NA	NA	MD 58 Gy	MD 63 Gy, V57 < 10 cc
Trachea, carina and main bronchus	NA	NA	MD 58 Gy	MD 63 Gy, V57 < 10cc
Rib	MD < 63 Gy	NA	V30 < 30 cc	MD 63 Gy; V30 < 30cc

¹Esophagus within the planning target volume ≤ 12 cm.

MD: Median dose; Dmax: Maximum dose; Fx: Fraction; ChT: Chemotherapy; NA: Not available.