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©The Author(s) 2022.
World J Clin Oncol. Mar 24, 2022; 13(3): 168-185
Published online Mar 24, 2022. doi: 10.5306/wjco.v13.i3.168
Published online Mar 24, 2022. doi: 10.5306/wjco.v13.i3.168
Figure 3 Wnt signaling regulatory mechanisms in intestinal cell development.
Wnt signaling balances intestinal development, morphogenesis and regeneration due to a gradient of Wnt pathway activity in epithelial layers with major activated cells (red) and minor activated cells (yellow). In Wnt-driven carcinogenesis, the gradient of Wnt pathway activity is lost and major activated, neoplastic cells (red) dominate. lncRNA: Long non-coding RNA; miRNAs: MicroRNAs.
- Citation: Swoboda J, Mittelsdorf P, Chen Y, Weiskirchen R, Stallhofer J, Schüle S, Gassler N. Intestinal Wnt in the transition from physiology to oncology. World J Clin Oncol 2022; 13(3): 168-185
- URL: https://www.wjgnet.com/2218-4333/full/v13/i3/168.htm
- DOI: https://dx.doi.org/10.5306/wjco.v13.i3.168