Intestinal Wnt in the transition from physiology to oncology

doi:10.5306/wjco.v13.i3.168

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Mar 24, 2022 (publication date) through Jul 28, 2024

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World Journal of Clinical Oncology

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2218-4333

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World J Clin Oncol. Mar 24, 2022; 13(3): 168-185
Published online Mar 24, 2022. doi: 10.5306/wjco.v13.i3.168

Table 2 Selection of potential target opportunities to inhibit Wnt/β-catenin signaling

Target	Effect	Ref.
Ligand-dependent Wnt signaling activation
Wnt ligands	Wnt inhibitors	[164]
	Posttranslational modification	[165]
Dkk1	Stabilization, increase of Dkk1	[128,166]
Transmembrane complex	Inhibition of Lgr5/6	[167]
	Inhibition of Frizzled	[168,169]
Dishevelled	Inhibition	[170]
Ligand independent Wnt signaling activation
Destruction complex	Stabilization of the destruction complex	[171,172]
β-catenin	Increase of degradation	[130,131]
β-catenin	Inhibition of translocation to the nucleolus	[173]
β-catenin cofactors		[174]
Ribosome biogenesis		[134]
Oncolytic viruses		[132,133]

Dkk1: Dickkopf 1.

Citation: Swoboda J, Mittelsdorf P, Chen Y, Weiskirchen R, Stallhofer J, Schüle S, Gassler N. Intestinal Wnt in the transition from physiology to oncology. World J Clin Oncol 2022; 13(3): 168-185
URL: https://www.wjgnet.com/2218-4333/full/v13/i3/168.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i3.168