Single-fraction stereotactic ablative body radiation therapy for primary and metastasic lung tumor: A new paradigm?

Table 1 Prospective data, single fraction stereotactic ablative body radiotherapy early-stage peripheral non-small cell lung cancer

Ref.	Design	Arms	n	Toxicity rates > GIII	LC	PFS	OS	FU3	SABR technique/prescription
Le et al[29], 2006	Phase I, n = 32	15 Gy (1fr)	9	0	54	NSCLC1: 67%	NSCLC1: 85%	18	Cyberknife
									Gold fiducials
									Breathold or Synchrony (Accuray) respiratory tracking system/Isodose coverage: 95% of PTV
		20 Gy (1fr)	1	0
		25 Gy (1fr)	20	1p (GIII)3p (GV)	91
						Metastatic1: 25%	Metastatic1: 56%
		30 Gy (1fr)	2	0
Videtic et al[30], 2015	Phase II, n = 84	48 Gy (4fr)	45	6 (13.3%)	92.7%1	71.1%2	77.7%2	30.2	Abdominal compression, gating with the respiratory cycle, tumor tracking, and active breath-holding techniques were allowed. Image guidance was required/prescription isodose surface ≥ 60% and < 90% of the maximun dose.
RTOG 0915
		34 Gy (1fr)	39	4 (10.3%)	97%1	56.4%2	62.3%2
Singh et al[31], 2019	Phase II, n = 98	60 Gy (3fr)	49	6 (15%)	97.1%1	50%2	62%2	53.8	Body Fix (Elekta) immobilizer. Real-Time Position Management by Varían Medical System or abdominal compression. 3D-CRT was preferred. Image guidance was required/tumor coverage and normal tissue dose constraints followed RTOG 0915
		30 Gy (1fr)	49	8 (17%)	94.9%2	65%2	73%2

¹At 1 yr.

²At 2 yr.

³Median follow-up months.

Fr: Fraction; RTOG: Radiation Therapy Oncology Group.