Oncologic safety of colonic stenting as a bridge to surgery in left-sided malignant colonic obstruction: Current evidence and prospects

Table 2 Long-term outcomes in randomized controlled trials of colonic stenting as a bridge to surgery

Ref.	Year	n	Perforation rate (%)	Median F/U time (mo)	Recurrence (%)	Overall survival (OS, %)	Disease-free survival (DFS, %)
Alcántara et al[47]	2011	28	0	38	SEMS, 53; ES, 15; (P = 0.055)	5-yr OS: SEMS, 60; ES, 68; (P = 0.843)	Disease-free period (mo): SEMS, 25; ES, 27; (P = 0.096)
Tung et al[74]	2013	48	0	32	SEMS, 46; ES, 13; (P = 0.400)	5-yr OS: SEMS, 48; ES, 27; (P = 0.076)	5-yr DFS: SEMS, 52; ES, 48; (P = 0.630)
Ghazal et al[48]	2013	60	0	18	SEMS, 17; ES, 13; (P = 0.228)	N/A	N/A
Sloothaak et al[57]	2014	58	23	43	SEMS, 50; ES, 28; (P = N/A)	4-yr OS: SEMS, 58; ES, 67; (P = 0.478)	4-yr DFS: SEMS, 30; ES, 49; (P=0.007)a
Arezzo et al[75]	2020	115	8.9	37	SEMS, 28; ES, 36; (P = N/A)	3-yr OS: SEMS, 63; ES, 68; (P = 0.822)	3-yr DFS: SEMS, 50; ES, 56; (P = 0.972)
CReST trial[53]	2022	2171	3.32	N/A	3-yr recurrence: SEMS, 43; ES, 34; (P = 0.340)	3-yr OS: SEMS, 46; ES, 37; (P = 0.560)	N/A

^aP<0.05

¹There are 217 potentially curative patients from 245 patients.

²The rate is reported in all patients (93% patients with potentially curable disease and 7%, palliative disease).

ES: Emergency surgery; SEMS: Self-expandable metal stent; N/A: Not available.