Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors

Figure 7 Phototherapeutic effects of photodynamic therapy on KB xenografts and body weight in mice. A: Tumor volume change is expressed as the relative tumor volume (volume on the indicated day/starting volume prior to the treatment. Tumors-treated by near-infrared photodynamic therapy (NIR-PDT) (50 J/cm²), irradiation alone (50 J/cm²), folate-Si-rhodamine-1 alone, and no treatment are shown in pink (○), gray (■), orange (●), and blue (□), respectively. Tumors-treated by NIR-PDT show significantly delayed growth compared to those of other groups. Values represent the mean ± SD (n = 8), ^aP < 0.05 NIR-PDT vs other groups; B: Average body weight did not differ significantly among the four groups of mice; C: Images of ex vivo tumors excised 16 d after treatment. FolateSiR-1: Folate-Si-rhodamine-1; NIR-PDT: Near-infrared photodynamic therapy; IR: Laser irradiation; CTR: Control.