Gut microbiota diversity and composition in predicting immunotherapy response and immunotherapy-related colitis in melanoma patients: A systematic review

Table 1 Risk of bias assessment with Risk of Bias In Non-randomised Studies - of Interventions

Ref.	Confounding	Selection	Intervention classification	Deviation from intervention	Missing data	Measurement of outcome	Selection of reported result	Overall
Dubin et al[33], 2016	Moderate	Low	Low	Low	Low	Low	Low	Moderate
Chaput et al[27], 2017	Moderate	Low	Low	Moderate	Low	Low	Moderate	Moderate
Gopalakrishnan et al[12], 2018	Moderate	Low	No information	Low	Low	Low	Low	Moderate
Matson et al[29], 2018	Moderate	No information	Serious	No information	No information	Low	Moderate	Serious
Peters et al[30], 2019	Moderate	Low	No information	No information	Low	Low	Low	Moderate
Baruch et al[26], 2020	Moderate	Low	Low	Low	Moderate	Low	Low	Moderate
Wind et al[31], 2020	Moderate	No information	No information	No information	No information	Low	Low	Moderate
Davar et al[28], 2021	Moderate	Moderate	Low	Low	No information	Low	Low	Moderate
Andrews et al[36], 2021	Moderate	Low	Low	Low	Low	Low	Low	Moderate