Neutrophil-to-lymphocyte ratio as a prognostic factor for survival in patients with colorectal liver metastases: A systematic review

Table 5 Survival and disease characteristics of patients that were treated with radio-frequency ablation, radioembolization or solely chemotherapy

Ref.	Median Survival	5-year OS	5-year DFS	Extrahepatic disease	Primary tumor	Chemotherapy
Tohme et al[29]	5.6 m high NLR 10.6 m low NLR	-	-	40 (less than 10% of tumor burden)	Some patients had undergone CRC resection (number not mentioned)	All patients
Chang et al[26]	-	-	(Preoperative NLR) 11.1% high NLR 22.6% low NLR (NLR increase after RFA 8.6%) (No postoperative NLR increase 22.2%)	No	All patients had undergone CRC resection	No mention
Zhang et al[27]	-	18,4% high NLR 41.7% low NLR	9.5% high NLR 26.7% low NLR	No	All patients had undergone CRC resection	If necessary after primary tumor resection (number not mentioned)
Weiner et al[28]	7.9 m high NLR 13 low NLR	-	-	59	79% had undergone primary CRC resection	All patients
Kishi et al[15]	11 m high NLR 21 m low NLR	0% high NLR 14% low NLR	-	No	All patients had undergone CRC resection	All patients
Wu et al[31]	24 m high NLR 56 m low NLR	-	-	No	All patients had undergone CRC resection	All patients
Philips et al[30]	14.7 m high NLR 31.9 m low NLR	-	-	Liver dominant disease	Not mentioned	All patients

RFA: Radio-frequency ablation; RE: Radioembolization; OS: Overall survival; DFS: Disease-free survival; NLR: Neutrophil to lymphocyte ratio; CRC: Colorectal cancer.