Neutrophil-to-lymphocyte ratio as a prognostic factor for survival in patients with colorectal liver metastases: A systematic review

Table 4 Patient demographics, NLR cut-off value, follow up and time of sample acquisition for patients treated with radio-frequency ablation, radioembolization or solely chemotherapy

Ref.	Number of patients and procedure	Sex	Mean age (yr)	NLR threshold	Follow up (mo)	Sample acquisition
Tohme et al[29]	104 RE	69 M, 35 F	60.8 ± 12.2, NLR > 5, 66.4 ± 12.2, NLR < 5	5	100 patients died during follow up	Same day before RE
Chang et al[26]	98 RFA	56 M, 42 F	62 (28-92)	2.5	35.2 ± 21.89	1 d before RFA - 1 mo after RFA
Zhang et al[27]	92 RFA	51 M, 41 F	59 (43-78)	5	27.1 ± 9.8 (range 5-62)	Preoperatively as part of the routine workup. 1-3 d before RFA
Weiner et al[28]	131 RE	84 M, 47 F	59	5	117 deaths during follow up	NS
Kishi et al[15]	90 chemotherapy	61 M, 29 F	56	5	28 (2-102)
Wu et al[31]	55 chemotherapy	35 M, 20 F	59	4	Complete clinical records (no exact mention)	Preoperatively and before 2nd cycle of chemotherapy
Philips et al[30]	71	-	-	5	-	-

RE: Radioembolization; RFA: Radiofrequency ablation; M: Male; F: Female; NLR: Neutrophil to lymphocyte ratio; NS: Not stated.