Neutrophil-to-lymphocyte ratio as a prognostic factor for survival in patients with colorectal liver metastases: A systematic review

Table 1 Patient demographics, neutrophil to lymphocyte ratio cut-off value, follow-up time and time of sample acquisition for patients after hepatectomy

Ref.	Number of patients	Sex	Mean age (years)	NLR threshold	Follow up (mo), mean (range)	Sample acquisition
Erstad et al[13]	151	84 M, 67 F	58	5	41.3 ± 36.7 (2-186)	Within 6 mo prior to surgery and prior to chemotherapy
Halazun et al[14]	440	289 M, 151 F	64 (32-88)	5	24 (11-97)	1 d prior to surgery
Kishi et al[15]	290	Resection group 132 M, 68 F; non resection group 61 M, 29 F	Resection, 57; non resection, 56	5	28 (2-102)	Resection group: Before chemotherapy and before resection
Neal et al[16]	302	192 M, 110 F	64.8 (26-85)	5	29.5 (4-96)	Prior to surgery
Hand et al[17]	322	205 M, 117 F	252 p < 70 yr; 70 p > 70 yr	5	41	On admission; the night prior to or on the morning of surgery
Peng et al[18]	150	97 M, 53 F	58 (20-82)	4.63	36 (2-126)	Within 7 d prior to surgery
Kim et al[19]	83	62 M, 21 F	59.5	1.94	NS	Within 1 wk prior to surgery
Mao et al[20]	183	123 M, 60 F	67 p > 60 yr	2.3	36.3	Within 10 d before chemotherapy and surgery
Neofytou et al[21]	140	88 M, 52 F	78% < 70 yr	2.4	33 (1-103)	Within 10 d prior to surgery
Giakoustidis et al[22]	169	104 Μ, 65 F	135 p < 70 yr, 34 p > 40 yr	2.5	34.6	10 d prior to surgery - after preoperative chemotherapy
Dupré et al[23]	343	236 M, 107 F	65.8 ± 10.9	2.5, 2.6 and 7.261	49	Within 1 wk prior to surgery
Hamada et al[24]	29	20 M, 9 F	63 ± 11.6 (41-83)	4.1	51 (2-97)	NS
Zeman et al[25]	130	70 M, 60 F	60 (33-82)	5	39.3	NS

¹Cut-off values that reached statistical significance.

M: Male; F: Female; p: Patients; NS: Not stated.