Somatic mutations in FAT cadherin family members constitute an underrecognized subtype of colorectal adenocarcinoma with unique clinicopathologic features

Table 3 Association of clinicopathologic features with FAT somatic mutations in colorectal adenocarcinoma (PanCancer Atlas)

Clinicopathologic features	Mutated FAT genes	Wildtype FAT genes	P value	Mutated FAT genes (MSS)	Wildtype FAT genes (MSS)	P value
Mean age (mean ± SD)	66.5 ± 12.9	65.3 ± 13.0	0.912	65.6 ± 12.1	65.3 ± 12.9
Sex			0.689			0.825
Female	98 (49.0%)	154 (47.2%)		67 (46.5%)	151 (47.3%)
Male	102 (51.0%)	170 (52.1%)		77 (53.5%)	166 (52.0%)
Location			< 0.001a			0.038a
Left side	65 (32.5%)	181 (55.5%)		70 (48.6%)	178 (55.8%)
Right side	102 (51.0)	98 (30.1%)		57 (39.6%)	92 (28.8%)
pT stage			0.093			0.083
pT1-2	50 (25.0%)	61 (18.7%)		38 (26.4%)	61 (19.1%)
pT3-4	150 (75.0%)	263 (80.7%)		106 (73.6%)	256 (80.3%)
pN stage			0.005a			0.079
pN0	133 (66.5%)	172 (52.8%)		87 (60.4%)	168 (52.7%)
pN1	44 (22.0%)	84 (25.8%)		39 (27.1%)	81 (25.4%)
pN2	23 (11.5%)	67 (20.6%)		18 (12.5%)	67 (21.0%)
pM stage			0.006a			0.038a
pM0	153 (76.5%)	235 (72.1%)		110 (76.4%)	228 (71.5%)
pM1	15 (7.5%)	53 (16.3%)		13 (9.0%)	53 (16.6%)
Differentiation grade			0.332			0.172
G1-2	145 (72.5%)	255 (78.2%)		117 (81.3%)	252 (79.0%)
G3	47 (23.5%)	67 (20.6%)		20 (13.9%)	63 (19.7%)
Subtype			< 0.001a
CIN	92 (46.0%)	236 (72.4%)
MSI	56 (28.0%)	7 (2.1%)
GS	25 (12.5%)	33 (10.1%)
Lymphovascular invasion			0.313			0.516
Positive	61 (30.5%)	117 (35.9%)		44 (30.6%)	113 (35.4%)
Negative	90 (45.0%)	140 (42.9%)		63 (43.8%)	139 (43.6%)
Total	200 (38.0%)	326 (62.0%)		144 (31.1%)	319 (68.9%)

^aP < 0.05.

CIN: Chromosomal instability; MSI: Microsatellite instability; GS: Genomically stable; MSS: Microsatellite stable.