Somatic mutations in FAT cadherin family members constitute an underrecognized subtype of colorectal adenocarcinoma with unique clinicopathologic features

Table 1 Clinicodemographics and histologic features in 526 patients with colorectal adenocarcinoma (PanCancer Atlas)

Feature	Level	Number	MSS number
Age (yr), mean ± SD		65.8 ± 13.0	65.4 ± 12.7
Gender	Female	252 (47.9%)	218 (47.1%)
	Male	272 (51.7%)	243 (52.5%)
	Unknown	2 (0.4%)	2 (0.4%)
Histopathologic differentiation	Well	19 (3.6%)	18 (3.9%)
	Moderate	381 (72.4%)	351 (75.8%)
	Poor	114 (21.7%)	83 (17.9%)
	Unknown	12 (2.3%)	11 (2.4%)
Tumor location	Left	254 (48.3%)	248 (53.6%)
	Right	197 (37.5%)	149 (32.2%)
	Left and right	3 (0.6%)	3 (6.5%)
	Unknown	72 (13.7%)	63 (13.6%)
Tumor staging (pT)	T1	18 (3.4%)	17 (3.7%)
	T2	94 (17.9%)	83 (17.9%)
	T3	355 (67.5%)	310 (67.0%)
	T4	57 (10.8%)	52 (11.2%)
	TX	2 (0.4%)	2 (0.4%)
Nodal staging (pN)	N0	305 (58.0%)	255 (55.1%)
	N1	128 (24.3%)	120 (25.9%)
	N2	90 (17.1%)	85 (18.4%)
	NX	3 (0.6%)	3 (6.5%)
Metastasis (pM)	M0	388 (73.8%)	338 (73.0%)
	M1	68 (12.9%)	66 (14.3%)
	MX	70 (13.3%)	59 (12.7%)
Lymphovascular invasion	Present	178 (33.8%)	157 (33.9%)
	Absent	230 (43.7%)	202 (43.6%)
	Unknown	118 (22.4%)	104 (22.5%)
Ethnicity	Caucasian	273 (51.9%)	236 (51.0%)
	African-American	60 (11.4%)	51 (11.0%)
	Asian	12 (2.3%)	11 (2.4%)
	Unknown	181 (34.4%)	165 (35.6%)
Subtype	CIN	328 (62.4%)
	MSI	63 (12.0%)
	GS	58 (11.0%)
	POLE	10 (1.9%)
	Unknown	57 (10.8%)
Total		526	463

CIN: Chromosomal instability; MSI: Microsatellite instability; GS: Genomically stable; POLE: Polymerase epsilon mutation; MSS: Microsatellite stable.