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©The Author(s) 2022.
World J Clin Oncol. Jan 24, 2022; 13(1): 28-38
Published online Jan 24, 2022. doi: 10.5306/wjco.v13.i1.28
Published online Jan 24, 2022. doi: 10.5306/wjco.v13.i1.28
Table 2 Results of phase 3 studies in first line treatment of patients with metastatic clear cell renal cell cancer
Drug/Study | No. of patients | Follow-up (mo) | PFS (mo) | OS (mo) | ORR, % | Ref. |
Nivolumab/Ipilimumab vs Sunitinib (Checkmate 214) | 1096 | 48 | ITT 12.2 vs 12.3; HR 0.89; I/P risk 11.2 vs 8.3; HR 0.74 | ITT NR vs 38.4; HR 0.69; I/P risk 48.1 vs 26.6; HR 0.65; F risk; HR 0.93 | ITT 39.1 vs 32.4; I/P risk 41.9 vs 26.8; F risk 29.6 vs 51.6 | [24] |
Pembrolizumab/Axitinib vs Sunitinib (Keynote 426) | 861 | 27 | ITT 15.4 vs 11.1; HR 0.71; P < 0.0001 | ITT NR vs 35.7; HR 0.68; P = 0.0003 | ITT 60 vs 40 | [39] |
Avelumab/Axitinib vs Sunitinib (Javelin 101) | 560 | 13 | ITT 13.3 vs 8; HR 0.69; P < 0.0001; PD-L1 + 13.8 vs 7; HR 0.62; P < 0.0001 | ITT NR; HR 0.80; P = 0.0392; PD-L1 + NR; HR 0.83; P = 0.1301 | ITT 52.5 vs 27.3; PD-L1 + 55.9 vs 27.3 | [44] |
Nivolumab/Cabozantinib vs Sunitinib (Checkmate 9ER) | 651 | 18.1 | ITT 16.6 vs 8.3; HR 0.51; P < 0.0001 | ITT NR vs NR; HR 0.60; P = 0.0010 | ITT 55.7 vs 27.1 | [45] |
Pembrolizumab/Lenvatinib vs Everolimus/Lenvatinib vs Sunitinib (Clear/Keynote 581) | 1069 | 26.6 | ITT Pembro/lenva vs sunitinib 23.9 vs 9.2; HR 0.39; P < 0.000; Everolimus/lenva vs sunitinib; 14.7 vs 9.2; HR 0.65; P < 0.0001 | ITT Pembro/lenva vs sunitinib NR vs NR; HR 0.66; P = 0.005; Evero/lenva vs sunitinib NR vs NR; HR 1.15; P = 0.30 | ITT Pembro/lenva vs Evero/lenva vs sunitinib; 71% vs 53.5% vs 36.1% | [41] |
- Citation: Popovic M, Matovina-Brko G, Jovic M, Popovic LS. Immunotherapy: A new standard in the treatment of metastatic clear cell renal cell carcinoma. World J Clin Oncol 2022; 13(1): 28-38
- URL: https://www.wjgnet.com/2218-4333/full/v13/i1/28.htm
- DOI: https://dx.doi.org/10.5306/wjco.v13.i1.28