Role of mammogram and ultrasound imaging in predicting breast cancer subtypes in screening and symptomatic patients

Table 7 Multinomial univariate logistic regressions: Impact of imaging features on relative odds of molecular subtypes

			Luminal A baseline			Luminal B baseline			DCIS baseline			HER2 enriched baseline			TNBC baseline
			P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI
Posterior acoustic features	Shadowing	Luminal A vs							d	3.27	(0.832 12.83)	b	7.35	(1.979 27.300)
		Luminal B vs										a	7.50	(1.307 43.030)
		DCIS vs	d	0.31	(0.078 1.202)
		HER2+ vs	b	0.14	(0.037 0.505)	a	0.13	(0.023 0.765)
		TNBC vs
	Enhancement	Luminal A vs													b	0.19	(0.055 0.633)
		Luminal B vs
		DCIS vs													a	0.12	(0.024 0.610)
		HER2+ vs													a	0.22	(0.058 0.807)
		TNBC vs	b	5.38	(1.581 18.310)				a	8.25	(1.638 41.55)	a	4.64	(1.239 17.38)
Margins (on US)	Spiculated	Luminal A vs				a	2.45	(1.130 5.31)	b	5.41	(1.931 15.14)	c	5.88	(2.544 13.58)	c	4.26	(1.805 10.056)
		Luminal B vs	a	0.41	(0.188 0.885)							d	2.40	(0.861 6.690)
		DCIS vs	b	0.19	(0.066 0.518)
		HER2+ vs	c	0.17	(0.074 0.393)	d	0.42	(0.150 1.16)
		TNBC vs	c	0.24	(0.099 0.554)
	Circumscribed	Luminal A vs													b	0.09	(0.019 0.445)
		Luminal B vs
		DCIS vs
		HER2+ vs
		TNBC vs	b	10.8	(2.246 52.043)
Size	Large	Luminal A vs										a	0.51	(0.258 0.999)	c	0.07	(0.024 0.208)
		Luminal B vs													c	0.08	(0.023 0.259)
		DCIS vs													c	0.04	(0.010 0.134)
		HER2+ vs	a	1.97	(1.001 3.878)										c	0.14	(0.043 0.450)
		TNBC vs	c	14.20	(4.811 41.915)	c	12.94	(3.856 43.427)	c	26.89	(7.445 97.114)	c	7.21	(2.224 23.354)
High-risk Microcals	Present	Luminal A vs							c	0.30	(0.154 0.583)	b	0.34	(0.171 0.665)
		Luminal B vs							d	0.44	(0.186 1.061)
		DCIS vs	c	3.34	(1.715 6.488)	d	2.25	(0.942 5.37)							b	4.50	(1.606 9.96)
		HER2+ vs	b	2.97	(1.504 5.844)										b	4.00	(1.824 11.10)
		TNBC vs							b	0.22	(0.090 0.548)		0.25	(0.100 0.623)
Adler	High	Luminal A vs										c	0.27	(0.131 0.566)	b	0.30	(0.142 0.618)
		Luminal B vs
		DCIS vs										d	0.38	(0.136 1.037)	d	0.41	(0.147 1.131)
		HER2+ vs	c	3.68	(1.767 7.650)				d	2.67	(0.965 7.37)
		TNBC vs	b	3.38	(1.618 7.045)				d	2.45	(0.884 6.78)
Axillary node adenopathy	Yes	Luminal A vs				a	3.08	(1.063 61.96)							a	0.44	(0.209 0.919)
		Luminal B vs	a	0.12	(0.224 0.470)							a	0.07	(0.009 0.556)	b	0.05	(0.007 0.430)
		DCIS vs
		HER2+ vs				a	14.40	(1.798 115.17)
		TNBC vs	a	2.28	(1.088 4.778)	b	18.50	(2.323 147.34)

^aSignificant at the 0.001 level.

^bSignificant at the 0.01 level.

^cSignificant at the 0.05 level.

^dSignificant at the 0.10 level.

Only statistically significant results are shown. Bold results show higher relative odds. DCIS: Ductal carcinoma in situ; TNBC: Triple-negative breast cancer; US: Ultrasound.