Re-irradiation for high-grade gliomas: Has anything changed?

Table 2 Summary of selected publications reporting hypofractionated stereotactic radiosurgery as salvage treatment in recurrent gliomas

Ref.	Study type	No. patients	Histology	Re-irradiation			Median interval	Median tumor volume	Median PFS2/actuarial PFS2	Median OS2	Severe toxicity	Radionecrosis
				Total dose, median	Dose/fr, median	EQD2
Selch et al[106], 2000	R	21	15 GBM, 3 G3G, 2 G2G, 1 no biopsy	25 Gy	5 Gy	43.8 Gy	11 mo	12 mL	5 mo	6.7 mo	0%	0%
Vordermark et al[107], 2005	R	19	9 GBM, 10 G2G	30 Gy	5 Gy	52.5 Gy	19 mo	15 mL	4.9 mo, 4.6 mo (GBM)	9.3 mo, 7.9 mo (GBM)	10.5% other than necrosis	0%
Ernst-stecken et al[108], 2007	P	15	10 GBM, 3 G3G. 2 G2G	35 Gy	7 Gy	78.7 Gy	10 mo	22.4 mL	15 mo	12 mo	20% need to increase steroids dose without evidence of progressive disease	NR
Fokas et al[78], 2009	P	53	All GBM	30 Gy	3 Gy	37.5 Gy	NR	35 mL	22% at 12 mo	9 mo	0%	0%
Fogh et al[29], 2010	R	147	105 GBM, 42 G3G	35 Gy	3.5 Gy	48.1 Gy	8 mo	22 mL	NR	11 mo (GBM)	0.7% toxicity (severe headaches)	0%
Mckenzie et al[69], 2013	P	33	29 GBM, 4 G3G	30 Gy	5 Gy	52.5 Gy	NR	8.54 mL	62% at 6 mo	8.6 mo	9% toxicity other than necrosis	9% by image
Ogura et al[80], 2013	R	30	15 GBM, 9 G3G. 6 G2G	35 Gy	7 Gy	78.7 Gy	NR	9 mL	3 mo	10.2 mo	13.3% need to increase steroids dose without evidence of progressive disease	6.1% by image
Miwa et al[109], 2014	P	21	All GBM	30 Gy	5 Gy	52.5 Gy	12 mo	27.4 mL	NR	11 mo	4.8%	9.5%
Dincoglan et al[110], 2015	R	28	All GBM	25 Gy	5 Gy	43.8 Gy	11.2 mo	36.5 mL	5.8 mo	10.3 mo	0%	11% G2 by image

α/β = 2; EQD2: Equivalent dose at 2 Gy fractions; G: Grade; G2G: Grade II glioma; G3G: Grade III glioma; GBM: Glioblastoma; NR: Not reported; OS2: Overall survival from re-irradiation; P: Prospective; R: Retrospective; PFS2: Progression free survival from re-irradiation.