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©The Author(s) 2021.
World J Clin Oncol. Sep 24, 2021; 12(9): 767-786
Published online Sep 24, 2021. doi: 10.5306/wjco.v12.i9.767
Published online Sep 24, 2021. doi: 10.5306/wjco.v12.i9.767
Table 1 Summary of selected publications reporting radiosurgery as salvage treatment in recurrent high-grade gliomas
Ref. | Study type | No. patients | Histology | Re-irradiation | Median interval | Median tumor volume | Median PFS2 | Median OS2 | Severe toxicity | Radionecrosis | |
Total dose, median | Dose/fr, median | ||||||||||
Combs et al[28], 2005 | R | 32 | All GBM | 15 Gy | 63.8 Gy | 10 mo | 10 mL | 7 mo | 10 mo | 0% | 0% |
Hsieh et al[104], 2005 | R | 26 | All GBM | 12 Gy | 42 Gy | NR | 21.6 mL | NR | 10 mo | NR | 31.3% by image |
Kong et al[34], 2008 | P | 114 | 65 GBM, 49 G3G | 16 Gy | 72 Gy | NR | 10.6 mL | 4.6 mo (GBM), 8.6 mo (G3G) | 13 mo (GBM), 26 mo (G3G) | 0% | 24.4% by image |
Patel et al[68], 2009 | R | 26 | All GBM | 18 Gy | 90 Gy | 12.5 mo | 10.4 mL | NR | 8.4 mo | Limited toxicity | NR |
Skeie et al[30], 2012 | R | 51 | All GBM | 12.2 Gy | 43.3 Gy | 11 mo | 12.4 mL | 6 mo | 12 mo | 0% | 0% |
Martínez-Carrillo et al[31], 2014 | R | 87 | 46 GBM, 41 G3G | 18 Gy | 90 Gy | 13.8 mo | 8.7 mL | NR | 7.5 mo (GBM); 17 mo (G3G) | 0% | 0% |
Kim et al[105], 2015 | R | 29 | All GBM | 15 Gy | 63.8 Gy | 8.8 mo | 11 mL | 3.6 mo | 9.2 mo | NR | NR |
- Citation: García-Cabezas S, Rivin del Campo E, Solivera-Vela J, Palacios-Eito A. Re-irradiation for high-grade gliomas: Has anything changed? World J Clin Oncol 2021; 12(9): 767-786
- URL: https://www.wjgnet.com/2218-4333/full/v12/i9/767.htm
- DOI: https://dx.doi.org/10.5306/wjco.v12.i9.767