Hematopoietic stem cell mobilization strategies to support high-dose chemotherapy: A focus on relapsed/refractory germ cell tumors

doi:10.5306/wjco.v12.i9.746

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World Journal of Clinical Oncology

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World J Clin Oncol. Sep 24, 2021; 12(9): 746-766
Published online Sep 24, 2021. doi: 10.5306/wjco.v12.i9.746

Table 2 Clinical studies applying plerixafor with granulocyte colony-stimulating factor ± chemotherapy for hematopoietic stem cells mobilization in patients with relapsed/refractory germ cell tumors

Ref.	Number of patients participating	Successful mobilization rates on previously failed chemotherapy + G-SCF driven mobilization (> 2 × 10⁶)	Mobilization techniques
Kobold et al[128] 2011 (Retrospective analysis)	6	66.67% (4)	Chemo + G-CSF failed
Kobold et al[128] 2011 (Retrospective analysis)	6	66.67% (4)	Plerixafor + G-CSF
Horwitz et al[162] 2012 (Retrospective analysis)	21	76% (17)	Chemo + G-CSF failed
Horwitz et al[162] 2012 (Retrospective analysis)	21	76% (17)	Plerixafor + G-CSF
Worel et al[163] 2012 (Retrospective analysis)	11	91% (10)	Plerixafor + G-CSF
Garcia-Escobar et al[164] 2014 (Case series)	5	80% (4)	Chemo + G-CSF failed
Garcia-Escobar et al[164] 2014 (Case series)	5	80% (4)	Plerixafor + G-CSF
Kosmas et al[165] 2014 (Pilot study)	14 (3)	100% (3)	Chemo + G-CSF failed
Kosmas et al[165] 2014 (Pilot study)	14 (3)	100% (3)	Chemo + Plerixafor + G-CSF
O’Hara et al[166] 2014 (Retrospective analysis)	9 (3)	100% (3)	Plerixafor + G-CSF

Related case studies: Saure et al[167], 2010; Tuffaha and Adel-Rahman[168], 2011; De Blasio et al[169], 2013; Miltiadous et al[170], 2017. G-CSF: Granulocyte colony-stimulating factor.

Citation: Porfyriou E, Letsa S, Kosmas C. Hematopoietic stem cell mobilization strategies to support high-dose chemotherapy: A focus on relapsed/refractory germ cell tumors. World J Clin Oncol 2021; 12(9): 746-766
URL: https://www.wjgnet.com/2218-4333/full/v12/i9/746.htm
DOI: https://dx.doi.org/10.5306/wjco.v12.i9.746