TRIM25: A central factor in breast cancer

Figure 2 Structure of TRIM25. A: Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains. (DNA sequence retrieved from NCBI. Gene, https://www.ncbi.nlm.nih.gov/gene/7706#gene-expression 21/01/21, and 3D model created with Swiss Model: https://swissmodel.expasy.org/); B: Schematic representation of TRIM25, including the conserved RING, B boxes (B1 and B2), the coiled-coil domain and the C-terminal variable domain (CTD) PRY-SPRY; C: RING and CTD domains bind to the ubiquitin-loaded E2 and the substrate, respectively. Consequently, both molecules get closer, therefore favoring substrate ubiquitination.