TRIM25: A central factor in breast cancer

Figure 1 TRIM25 is an E3-ligase common for interferon-stimulated gene 15 and ubiquitin proteins. A: The ISGylation system; B: The Ubiquitination system. The ISGylation system and the ubiquitination system are similar, however, the ubiquitination system has more than 600 E3 ligases and the ISGyaltion system has three E3 ligases. Interestingly, both systems have in common the E3 ligase tripartite motif containing 25. ISG15: Interferon-stimulated gene 15; DUBs: Ubiquitin-proteasome system; Ub: Ubiquitin; USP18: Ubiquitin-specific protease 18.