Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers: State of art and an innovative approach for prevention

Table 1 Incidence of chemotherapy-induced peripheral neuropathy

Trail	Indication	No. of patients	Treatment	Grade 1 (%)	Grade 2 (%)	Grade 3 (%)
AGO OVAR 3[35]	FIGO IIB-IV fist line	388	CP	39	28	6.7
		384	PP	33	36	12.5
JGOG[29]	FIGO II-IV fist line	319	CP			20 (6)
		312	C-P			21 (7)
MITO 4[27]	FIGO IC-IV fist line	120	CP	51 (42)	13 (11)	1 (1)
MITO 2[26]	FIGO IC-IV fist line	407	CP	115 (28)	64 (16)	12 (3)
		396	C-PLD	47 (12)	11 (3)	1 (< 1)
MITO 7[28]	FIGO IC-IV fist line	404	CP	95 (24)	58 (15)	8 (2)
		406	CP weekly	98 (25)	24 (6)	0
ICON 4[2]	Platinum-sensitive relapse > 6 mo	410	P-based		4 (1)
		392	CP/PP		76 (20)

CP: Carboplatin area under the curve (AUC) 5/6 mg/mL per min plus paclitaxel 175-185 mg/mq every 3 wk; CP weekly: Carboplatin AUC 2 mg/mL per min plus paclitaxel 60 mg/mq every week; C-P: Carboplatin AUC 6 mg/mL per min every 3 wk plus paclitaxel 80 mg/mq on days 1, 8, 15, and every 21 d; C-PLD: Carboplatin AUC 5 mg/mL per minute plus pegylated liposomial doxorubicin 30 mg/mq every 3 wk; P-based: Cisplatin (50 mg/mq in combination with other drugs or 75 mg/mq as a single agent)/carboplatin AUC 5/6 mg/mL every 3 wk; PP: Cisplatin 75 mg/mq plus paclitaxel 175 mg/mq every 3 wk.