Immune response evaluation criteria in solid tumors for assessment of atypical responses after immunotherapy

Figure 4 Axial computed tomography images in the portal-venous phase of a 57 y/o female ex-smoker with non-small lung cell carcinoma during second-line treatment with Pembrolizumab. Images show a dissociated response of two target lesions. A: The left peri-hilar lesion progressively decreased in size during follow-up, if compared to the pre-treatment computed tomography scan (after 3 wk and after 9 wk of immunotherapy from left to right, respectively); B: The second target lesion in left lung firstly regressed after 3 wk of immunotherapy showing, then a progression during the follow-up period (from left to right, respectively).