Overview of recent advances in metastatic triple negative breast cancer

doi:10.5306/wjco.v12.i3.164

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Mar 24, 2021 (publication date) through Mar 7, 2025

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Mar 24, 2021; 12(3): 164-182
Published online Mar 24, 2021. doi: 10.5306/wjco.v12.i3.164

Table 5 Pivotal Phase III studies of poly adenosine diphosphate ribose polymerase inhibitors in patients with germline BRCA1/BRCA2 mutations

Trial	n	Drug	Median PFS (mo) 1^st line	Media PFS (mo) ≥ 1 line	Media OS (mo) 1^st line	Media OS (mo) ≥ 1 line	Ref.
OLYMPIAD	296	Olaparib		7.3		19.3	Robson et al[67], 2017
EMBRCA	431	Talazoparib		8.6		19.6	Litton et al[69], 2020
BROCADE3 (1^st line)	337	Veliparib	14.5		33.5		Bardia et al[77], 2020

PFS: Progression free survival; OS: Overall survival.

Citation: O'Reilly D, Sendi MA, Kelly CM. Overview of recent advances in metastatic triple negative breast cancer. World J Clin Oncol 2021; 12(3): 164-182
URL: https://www.wjgnet.com/2218-4333/full/v12/i3/164.htm
DOI: https://dx.doi.org/10.5306/wjco.v12.i3.164