GOECP/SEOR radiotherapy guidelines for small-cell lung cancer

Table 5 Planning volumes in the principal studies of concurrent chemoradiotherapy in small cell lung cancer

Ref.	Study	Volume
Jeremic et al[41] 1999	Prospective, randomised	GTV + hilum + 2 cm; entire mediastinum + both supraclavicular fossae + 1 cm
Zhu et al[116] 2011	Retrospective	Primary GTV + GTVn > 1 cm short axis
Yee et al[117] 2012	Prospective, phase II	GTVp + GTVn visible on planning CT
Slotman et al[44] 2015	Phase III, randomised	GTVp post-CT + 15 mm + ipsilateral hilum + nodes involved pre-CT
Luan et al[119] 2015	Retrospective	CR post-CT: Primary GTV bed and GTVn involved pre-CT; SD post-CT: GTVp + GTVn; PD post-CT: New GTVp + GTVn + GTV
Qin et al[118] 2016	Retrospective	GTV: Thoracic, mediastinal, and supraclavicular fossae
Gore et al[47] 2017	Phase II, randomised	Post-CT volume including the primary tumour and nodal areas involved at diagnosis
Luo et al[120] 2017	Retrospective	Post-CT GTVp + pre-CT primary tumour bed + GTVn of nodes involved pre-CT
Zhang et al[121] 2017	Literature review	CR: Mediastinum initially involved; PR: Residual pulmonary lesions + initially involved lymph nodes

GTV: Gross tumour volume; GTVn: Lymph node gross tumour volume; GTVp: Primary gross tumour volume; CT: Computed tomography; CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease.