Copyright
©The Author(s) 2021.
World J Clin Oncol. Dec 24, 2021; 12(12): 1101-1156
Published online Dec 24, 2021. doi: 10.5306/wjco.v12.i12.1101
Published online Dec 24, 2021. doi: 10.5306/wjco.v12.i12.1101
Figure 2 Summary of ligand binding to epidermal growth factor receptor in liver regeneration.
Endocrine EGFR signalling by EGF from Brunner’s glands and salivary glands. Paracrine EGFR signalling by HB EGF from LSEC and Kupffer cells, autocrine EGFR signalling by amphiregulin and TGFα from hepatocytes. LSEC: Liver sinusoidal endothelial cell; EGF: Epidermal growth factor; EGFR: Epidermal growth factor receptor; HB EGF: Heparin bound EGF-like growth factor; TGFα: Transforming growth factor α.
- Citation: Hadjittofi C, Feretis M, Martin J, Harper S, Huguet E. Liver regeneration biology: Implications for liver tumour therapies. World J Clin Oncol 2021; 12(12): 1101-1156
- URL: https://www.wjgnet.com/2218-4333/full/v12/i12/1101.htm
- DOI: https://dx.doi.org/10.5306/wjco.v12.i12.1101