Immunotherapy combinations and chemotherapy sparing schemes in first line non-small cell lung cancer

Table 3 Summary of the main toxicities in each of the studies on immunotherapy combinations or immunotherapy ± chemotherapy

Phase II-III studies	G3-4 toxicity (%)		Treatment discontinuation (%)
	Exp arm	Control arm	Exp arm	Control arm
CM 227	32.8 NI	33.8 CT	9.4 NI	3.4 CT
MYSTIC	22.9 DT	36 CT	12.3 DT	4.9 CT
CM9LA	47 NI-CT	38 CT	16 NI-CT	9 CT
CCTG-BG-34	82 DT-CT	70 DT	NA	NA
CITYSCAPE	19 ATir	14 PA	10.3 ATir	7.5 PlA
KEYNOTE-189	67 P-CT	65.8 CT	13.8 P-CT	7.9 CT

NI: Nivolumab + ipilimumab; DT: Durvalumab+ tremelimumab; CT: Chemotherapy; Tir: Tirogolumab; A: Atezolizumab; PL: Placebo; P-CT: Pembrolizumab + chemotherapy; NA: Not available.