New challenges in the combination of radiotherapy and immunotherapy in non-small cell lung cancer

doi:10.5306/wjco.v12.i11.983

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Nov 24, 2021 (publication date) through Jan 8, 2025

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World Journal of Clinical Oncology

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World J Clin Oncol. Nov 24, 2021; 12(11): 983-999
Published online Nov 24, 2021. doi: 10.5306/wjco.v12.i11.983

Table 5 Ongoing clinical trials involving radiotherapy and immunotherapy in stage IV non-small cell lung cancer

Ref.	Phase	ICI agent	RT dose	Design	Primary endpoints
NCT03158883[93]	I	Avelumab	50 Gy/5 fx	ICI + SABR	ORR
NCT03224871[94]	I	Nivolumab; Pembrolizumab; Intratumor IL-2	8 Gy/3 fx	ICI + IL-2 + RT	MTD
NCT03436056, PRIMING[95]	I	Pembrolizumab	SABR 30 Gy-3 fx SABR 54 Gy/3 fx	ICI + SABR	MTD
NCT03812549[96]	I	Sintilimab	SABR 30 Gy/3 fx; LD (low dose)-RT: 2 Gy/1 fx or 4 Gy/2 fx or 10 Gy/5 fx	ICI + SABR; ICI + LD-RT	MTD
NCT03223155, COSINR[69]	I	Nivolumab; Ipilimumab	SABR 3-5 fx, 2-4 sites	ICI + SABR	MTD
NCT02639026[97]	I	Durvalumab; Tremelimumab	HFRT 24 Gy/3 fx, 17 Gy/1 fx	ICI + HFRT	MTD
NCT03275597[98]	I	Durvalumab; Tremelimumab	SABR 30-50 Gy/5 fx	ICI + SABR	MTD
NCT03168464[99]	I-II	Nivolumab; Ipilimumab	RT 30 Gy/5 fx	ICI + RT	ORR
NCT02239900[100]	I-IIR	Ipilimumab	SABR 50 Gy/4 fx or 60 Gy/10 fx; 1-4 lesions	ICI + SABR	MTD
NCT02444741[101]	I-IIR	Pembrolizumab	SABR 4 fx or IMRT, PBRT, 3D-CRT 15 fx	ICI + SABR or IMRT, PBRT, 3D-CRT	MTD, ORR
NCT03176173, RRADICAL[102]	II	Nivolumab; Pembrolizumab; Atezolizumab	SABR 1-10 fx	ICI +/- SABR	PFS
NCT03965468, CHESS[103]	II	Durvalumab	SABR 1-10 fx	ICI + SABR + CT	PFS
NCT03044626, FORCE[104]	II	Nivolumab	RT 20 Gy/5 fx	ICI + RT	ORR
NCT02221739[105]	II	Ipilimumab	IMRT or 3D-CRT 30 Gy/5 fx	ICI + RT	ORR
NCT02658097[106]	II	Pembrolizumab	RT 8 Gy/1 fx	ICI + RT	ORR
NCT03391869, LONESTAR[107]	III	Nivolumab; Ipilimumab	LCT	ICI +/- SABR	OS
NCT03867175[108]	III	Pembrolizumab	SABR 3-10 fx	ICI +/- SABR	PFS
NCT03774732, NIRVANA-LUNG[109]	III	Pembrolizumab	SABR or 3D-CRT 18 Gy/3 fx	ICI + RT + CT	OS

ICI: Immune checkpoint inhibitors; Fx: Fraction; SABR: Stereotactic ablative radiotherapy; RT: Radiotherapy; LD-RT: Low dose radiotherapy; HFRT: Hypofractionated radiotherapy; IMRT: Intensity modulated radiotherapy; PBRT: Proton beam radiation therapy; 3D-CRT: 3D conformal radiation therapy; LCT: Local consolidation therapy; CT: Chemotherapy; ORR: Overall response rate; MTD: Maximum tolerated dose.

Citation: Luna J, Zafra J, Areses Manrique MC, Rodríguez A, Sotoca A, Fírvida JL, Chicas-Sett R, Mielgo X, Reyes JCT, Couñago F. New challenges in the combination of radiotherapy and immunotherapy in non-small cell lung cancer. World J Clin Oncol 2021; 12(11): 983-999
URL: https://www.wjgnet.com/2218-4333/full/v12/i11/983.htm
DOI: https://dx.doi.org/10.5306/wjco.v12.i11.983