New challenges in the combination of radiotherapy and immunotherapy in non-small cell lung cancer

Table 1 Ongoing clinical trials of stereotactic ablative radiotherapy and immune checkpoint inhibitors combination in early-stage non-small cell lung cancer

Ref.	Phase	n	Stage	SABR dose	ICI agent	ICI sequence	Status
NCT03833154[38]	III randomized	706	I-II	NM; 3-8 fx	Durvalumab	Sequential	Recruiting
NCT04214262[39]	III randomized	460	I-II	NM; 3-5 fx	Atezolizumab	Concurrent	Recruiting
NCT03110978[40]	II randomized	140	I-IIA	50 Gy/4 fx; 70 Gy/10 fx	Nivolumab	Concurrent	Recruiting
NCT03446547[41]	II randomized	216	I	NM; 3-4 fx	Durvalumab	Sequential	Recruiting
NCT03148327[42]	I-II randomized	105	I-IIA	54 Gy/3 fx; 50 Gy/4 fx; 65 Gy/10 fx	Durvalumab	Concurrent	Recruiting
NCT03050554[43]	I-II	56	I	48 Gy/4 fx; 50 Gy/5 fx	Avelumab	Concurrent	Not recruiting
NCT03383302[44]	I-II	31	I-II	54 Gy/3 fx; 55 Gy/5 fx	Nivolumab	Sequential	Recruiting
NCT02599454[45]	I	33	I	50 Gy/4 fx; 50 Gy/5 fx	Atezolizumab	Induction	Not recruiting

SABR: Stereotactic ablative body radiotherapy; ICI: Immune checkpoint inhibitor; Gy: Gray; NM: Not mentioned.