Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients

Figure 2 Survival curves of circulatory markers kynurenine, interleukin-6, neutrophil-lymphocyte ratio and human telomerase reverse transcriptase(red indicates worse prognosis while green represents favorable prognosis), differential survival between astrocytic isocitrate dehydrogenase-mutant and isocitrate dehydrogenase-wildtype gliomas, combination receiver operating characteristic of the panel of kynurenine, interleukin-6, neutrophil-lymphocyte ratio, and human telomerase reverse transcriptase to achieve increased sensitivity and specificity for predicting overall survival. A: Kynurenine; B: Interleukin-6; C: Neutrophil-lymphocyte ratio; D: Human telomerase reverse transcriptase; E: Differential survival between astrocytic isocitrate dehydrogenase-mutant and wildtype gliomas; F: Combination receiver operating characteristic of the panel of kynurenine, interleukin-6, neutrophil-lymphocyte ratio, and human telomerase reverse transcriptase to achieve increased sensitivity and specificity for predicting overall survival. KYN: Kynurenine; IL-6: Interleukin-6; hTERT: Human telomerase reverse transcriptase; NLR: Neutrophil- lymphocyte ratio; IDH-m astro: Isocitrate dehydrogenase mutant astrocytic; IDH-w astro: Isocitrate dehydrogenase wildtype astrocytic.