Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients

Table 4 Univariate and multivariate Cox regression analysis of variables

No.	Variable	Univariate		Multivariate
		HR (95%CI)	P value	HR (95%CI)	P value
1	KYN (ng/mL)	1.0037 (1.0026-1.0048)	0.0001c	1.0024 (1.0011-1.0037)	0.0003c
2	IL-6 (pg/mL)	1.0032 (1.0021-1.0042)	0.0001c	1.0022 (1.0010-1.0035)	0.0004c
3	NLR	1.2437 (1.1621-1.3312)	0.0001c	1.2085 (1.1138-1.3114)	0.0001c
4	TIMP-1 (ng/mL)	1.0150 (1.0075-1.0225)	0.0001c	1.0046 (0.9975-1.0118)	0.2042
5	hTERT (ng/mL)	1.2681 (1.1498-1.3987)	0.0001c	1.2303 (1.0749-1.4080)	0.0026b
5	Age(yr)	1.0245 (1.0108-1.0383)	0.0004c	1.0090 (0.9938-1.0233)	0.2165
6	EOR	1.3379 (1.8805-3.0328)	0.1726	NA	NA
7	Site	0.9527 (0.6221-1.4589)	0.8236	NA	NA
8	Therapy	0.8507 (0.2201-1.3578)	0.906	NA	NA

^bP < 0.01.

^cP < 0.001; indicated a significant association.

Results are presented as estimated hazards ratio with 95% confidence interval for specific variables. Variables with a significant P value (< 0.05) in univariate Cox-regression model were selected and analyzed using multivariate Cox-regression. CI: Confidence interval; EOR: Extent of resection; HR: Hazard ratio; hTERT: Human telomerase reverse transcriptase; KYN: Kynurenine; IL-6: Interleukin-6; NA: Not assessed; NLR: Neutrophil-lymphocytes ratio; TIMP-1: Tissue inhibitor metalloproteases-1.