Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients

Table 3 Spearman coefficient correlation of circulatory markers with overall survival, histological grade and Kynurenine

No.	Circulatory markers	Spearman r	95%CI	P value
	Correlation with OS
1	KYN (ng/mL)	-0.6154	-0.7324 to -0.463	< 0.0001c
2	IL-6 (pg/mL)	-0.5531	-0.6854 to -0.3855	< 0.0001c
3	NLR	-0.5696	-0.698 to -0.4058	< 0.0001c
4	TIMP-1 (ng/mL)	-0.4831	-0.6312 to -0.3011	< 0.0001c
5	hTERT (ng/mL)	-0.4386	-0.5960 to -0.2489	< 0.0001c
	Correlation with grade
6	KYN (ng/mL)	0.5409	0.3705 to 0.6761	< 0.0001c
7	IL-6 (pg/mL)	0.6400	0.4944 to 0.7507	< 0.0001c
8	NLR	0.4982	0.3190 to 0.6430	< 0.0001c
9	TIMP-1 (ng/mL)	0.2614	0.05118 to 0.4495	0.0128a
10	hTERT (ng/mL)	0.3000	0.06441 to 0.4834	0.0102a
	Correlation with KYN
11	IL-6 (pg/mL)	0.4919	0.3115 to 0.638	< 0.0001c
12	NLR	0.4084	0.214 to 0.5717	< 0.0001c
13	TIMP-1 (ng/mL)	0.4718	0.2877 to 0.6223	< 0.0001c
14	hTERT (ng/mL)	0.3504	0.1485 to 0.5243	0.0007c

^aP < 0.05.

^cP < 0.001.

An extremely significant inverse correlation of kynurenine, interleukin-6, neutrophil-lymphocytes ratio, tissue inhibitor metalloproteases-1 and human telomerase reverse transcriptase was obtained with respect to overall survival. A significant positive correlation of interleukin-6, neutrophil-lymphocytes ratio, tissue inhibitor metalloproteases-1 and human telomerase reverse transcriptase was obtained with respect to grades and kynurenine circulatory levels. OS: Overall survival; KYN: Kynurenine; IL-6: Interleukin-6; NLR:Neutrophil lymphocytes ratio; TIMP-1: Tissue inhibitor metalloproteases-1; hTERT: Human telomerase reverse transcriptase; CI: Confidence interval.