Evolutionary model of brain tumor circulating cells: Cellular galaxy

Figure 4 The harmonic ratio of tumor cells with different degree of expression intensity for protein C-C chemokine ligand 2, vascular endothelial growth factor, and epidermal growth factor to the circulating tumor cells in patients with brain tumors. C-C chemokine ligand 2 (CCL2), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) are conjugated with fluorescein isothiocyanate, R-phycoerythrin, and phycoerythrin–indodicarbocyanine, respectively. The highlighted quadrants with different colors indicate the harmonic evolutionary altered intensity including increased and/or decreased ratio value of the related proteins in common between different patients or within different proteins. The altered ratio is based on the provided data in Figure 1; Numbers 1 (high), 2 (medium) and 3 (low) are reflective of expression intensity of proteins CCL, VEGF and EGF. C: C-C chemokine ligand 2; V: Vascular endothelial growth factor; E: Epidermal growth factor.