Evolutionary model of brain tumor circulating cells: Cellular galaxy

Figure 3 Ratio of co-expression of proteins between tumor cells in tumor region to circulating tumor cells and vasculature system for proteins C-C chemokine ligand 2, vascular endothelial growth factor, and epidermal growth factor in 18 patients with brain tumor. A: The ratio of co-expression between proteins C-C chemokine ligand 2 (CCL2), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) traced in tumor cells to the migrated tumor cells in the blood and the vascular system of patients with meningioma (pts. 1-14); B: The ratio of co-expression between proteins CCL2, VEGF, and EGF traced in tumor cells to the migrated tumor cells in the blood and the vascular system of patients with brain cancer (pts. 15-18). The highlighted quadrants with different colors indicate the harmonic evolutionary altered intensity of related proteins in common amongst different patients. Pr. Exp.: Protein expression; ID: Patients’ identification; C: C-C chemokine ligand 2; V: Vascular endothelial growth factor; E: Epidermal growth factor; Ves: Vesicles; Vas: Vasculature; MV: Microvesicles (angiogenesis).