Diacerein treatment prevents colitis-associated cancer in mice

Figure 2 Diacerein treatment attenuates the expression of pro-inflammatory cytokines. A: Quantitative reverse transcription polymerase chain reaction analysis of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α genes in peritumoral colonic tissue of Swiss mice treated with vehicle or diacerein50 (n = 17–18 mice/group); B: Quantification of serum IL-1β, IL-6 and TNF-α (n = 6–10 mice/group); C: Analysis of pro-inflammatory protein expression (p-IKK, p-JNK) by immunoblot in the peritumoral colonic tissue (Supplementary Figure 1). Data are presented as mean ± standard error. ^aP < 0.05.