Diacerein treatment prevents colitis-associated cancer in mice

Figure 1 Diacerein treatment suppresses chemically induced colitis. Swiss mice that underwent colitis induction by a single dose of azoxymethane and dextran sulphate sodium were randomly divided into four groups, control (CTL) and diacerein (DAR) 10 (treated with 10 mg/kg/d), DAR20 (treated with 20 mg/kg/d) and DAR50 (treated with 50 mg/kg/d). A: Inflammatory index and microphotographic representation of colon sections (magnification 20 ×) stained with hematoxylin and eosin in CTL and DAR groups, scale bar: 100 µm; B: Number of bleeding rectal episodes over time; C: Time to first rectal bleeding episode; D: Number of episodes of diarrhea over time in Swiss mice; E: Time to the first episode of diarrhea; F: Overall survival of Swiss animals in CTL and DAR50-treated groups; G: Body weight. Data are presented as mean ± standard error. ^aP < 0.05.