B-cell lymphoma-2 inhibition and resistance in acute myeloid leukemia

Figure 1 Diagram of the intrinsic apoptotic pathway. When a cell stress or damage signal is received, pro-apoptotic proteins inhibit the anti-apoptotic proteins leading to the subsequent release of effector proteins, BAX and BAK. This induces mitochondrial outer membrane permealization and allows for the release of cytochrome C. Cytochrome C binds to Apoptotic protease activating factor 1, which leads to the formation of the apoptosome, release of caspases, and ultimately, cell death. Venetoclax inhibits B-cell lymphoma-2. Bcl-2: B-cell lymphoma-2; MOMP: Mitochondrial outer membrane permealization; APAF1: Apoptotic protease activating factor 1.