B-cell lymphoma-2 inhibition and resistance in acute myeloid leukemia

doi:10.5306/wjco.v11.i8.528

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World Journal of Clinical Oncology

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World J Clin Oncol. Aug 24, 2020; 11(8): 528-540
Published online Aug 24, 2020. doi: 10.5306/wjco.v11.i8.528

Table 1 Clinical trials investigating venetoclax combination therapy

ClinicalTrials.gov identifier	Treatment combination	Phase	Population
NCT03709758	Venetoclax + daunorubicin + cytarabine	Ib	Untreated
NCT03214562	Venetoclax + fludarabine, cytarabine, filgrastim, idarubicin	Ib/II	Untreated Relapsed/refractory
NCT03471260	Venetoclax + ivosidenib ± azacitidine	I/II	Relapsed/refractory
NCT02993523	Venetoclax + placebo or azacitidine	III	Untreated
NCT03069352	Venetoclax + placebo or low dose cytarabine	III	Untreated
NCT03466294	Venetoclax + azacitidine	II	Untreated-elderly
NCT03404193	Venetoclax + decitabine 10 d	II	Untreated
NCT03586609	Venetoclax + low dose cytarabine+ cladribine + azacitidine	II	Untreated
NCT03236857	Venetoclax ± chemotherapy (various)	I	Relapsed/refractory malignancies (including AML)
NCT03455504	Venetoclax + fludarabine + cytarabine + idarubicin	II	Untreated
NCT03629171	Venetoclax + liposomal daunorubicin -cytarabine	II	Untreated Relapsed/refractory
NCT03862157	Venetoclax + azacitidine + pevonedistat	I/II	Untreated
NCT03390296	Venetoclax + azacitidine + avelumab	I/II	Untreated
NCT03390296	Venetoclax + azacitidine + gemtuzumab ozogamicin + anti-OX40 antibody	I/II	Relapsed/refractory
NCT03867682	Venetoclax + lintuzumab-Ac225	I/II	Relapsed/refractory
NCT03932318	Venetoclax + azacitidine + lintuzumab-Ac225	I/II	Relapsed/refractory
NCT03672695	Venetoclax + S64315	I	Relapsed/refractory
NCT03797261	Venetoclax + AMG-176	Ib	Relapsed/refractory
NCT03063944	Venetoclax + decitabine + OPB-111077	Ib/II	Relapsed/refractory
NCT03484520	Venetoclax + dinaciclib	Ib	Relapsed/refractory
NCT03441555	Venetoclax + alvocidib	Ib	Relapsed/refractory
NCT02670044	Venetoclax + cobimetinib; Venetoclax + idasanutlin	I/II	Relapsed/refractory
NCT03940352	Venetoclax + HDM201	I	Relapsed/refractory
NCT03874052	Venetoclax + ruxolitinib	I	Relapsed/refractory
NCT03471260	Venetoclax + ivosidenib	Ib/II	Relapsed/refractory
NCT04092179	Venetoclax + enasidenib	Ib/II	Relapsed/refractory
NCT03735875	Venetoclax + quizartinib	Ib/II	Relapsed/refractory
NCT03625505	Venetoclax + gilteritinib	I	Relapsed/refractory

AML: Acute myeloid leukemia.

Citation: Wilde L, Ramanathan S, Kasner M. B-cell lymphoma-2 inhibition and resistance in acute myeloid leukemia. World J Clin Oncol 2020; 11(8): 528-540
URL: https://www.wjgnet.com/2218-4333/full/v11/i8/528.htm
DOI: https://dx.doi.org/10.5306/wjco.v11.i8.528