MUTYH: Not just polyposis

Figure 1 MUTYH functional domains and its binding partners (see UniProtKB - E5KP25). RPA: Replication protein A; MSH6: MutS 6 homolog; APE1: AP endonuclease 1; PCNA: Proliferating cell nuclear antigen; HUS1: Checkpoint clamp component. APE1, PCNA and well-known representative typical mutations of MUTYH (see all variants in ClinVar database); the mutation nomenclature is based on MUTYH longest transcript.