Role of imaging biomarkers in mutation-driven non-small cell lung cancer

Figure 2 Primary tumor features and “miliary” type metastases in 66-year-old male non-smoker with EGFR-mutant non-small cell lung cancer. A: Pretreatment computed tomography (CT) shows a mass-like consolidation in the left upper lobe with internal air bronchograms (arrowheads) and diffuse 1-2 mm nodules bilaterally consistent with “miliary” metastases. Consolidative, “pneumonic”, appearance of the primary tumor is associated with EGFR mutations in non-small cell lung cancer; B: Post-treatment CT shows marked treatment response to targeted therapy with mild residual scarring and nodularity in the left upper lobe and near-complete resolution of diffuse metastases.