Role of microRNA dysregulation in childhood acute leukemias: Diagnostics, monitoring and therapeutics: A comprehensive review

Figure 1 Examples of microRNAs that may exert contrasting oncogenic/tumor-suppressive effects on tumor-modifying extrinsic factors and the leukemic cells themselves (modified from Svoronos et al[19], with the permission of the author). Green arrows, positive regulation; orange arrows, negative regulation; blue arrows, either positive or negative regulation. A narrow extension directly from a microRNA to the central leukemic cell refers to promotion/inhibition of leukemic cell progression/survival through the microRNA’s direct regulation of leukemic cell–endogenous mRNAs.