Preoperative markers for the prediction of high-risk features in endometrial cancer

Table 4 Cut-off values of cancer antigen 125 and HE4 to predict high-risk features in clinical stage 1 postmenopausal endometrial cancer patients

	Cut-off value	AUC	P value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
CA125	20 U/mL	0.72	0.002	64.0	72.3	69.8	66.8
HE4	113 pmol/L	0.70	0.006	64.0	77.3	73.8	68.2

AUC: Area under the concentration-time curve; PPV: Positive predictive value; NPV: Negative predictive value; CA125: Cancer antigen 125; HE4: Human epididymis protein 4.