Preoperative markers for the prediction of high-risk features in endometrial cancer

Table 2 Comparison of clinical characteristics between endometrial cancer patients with and without high-risk features¹, n (%)

Characteristics	Patients with high-risk features (n = 74)	Patients without high-risk features (n = 54)	P value
Age (yr), mean ± SD	60.1 ± 10.7	53.7 ± 10.2	0.001
BMI (kg/m2), mean ± SD	27.1 ± 7.8	28.5 ± 7.1	0.32
Obese (BMI > 30 kg/m2)	16 (21.6)	21 (38.9)	0.05
Nulliparous	41 (47.7)	26 (48.1)	0.48
Postmenopause	59 (79.7)	30 (55.6)	0.006
Coexisting medical diseases	46 (62.2)	34 (63.0)	1.00
Coexisting benign gynecologic diseases	42 (56.8)	30 (55.56)	1.00
CA125 level, median (min-max)	27.0 (7.1-786.8)	16.3 (5.3-432.1)	0.002
HE4 level, median (min-max)	130.6 (39.4-1719.0)	81.7 (30.5-293.9)	0.005

¹High risk features included grade 3 tumors, large tumor sizes, deep myometrial invasion, lymphovascular space invasion, cervical metastasis, extrauterine metastasis and nodal metastasis. BMI: Body mass index; CA125: Cancer antigen 125; HE4: Human epididymis protein 4.