Impact of primary tumour location on colorectal liver metastases: A systematic review

Table 3 Disease free survival data

Ref.	Year	Median DFS (mo)				3 yr DFS (%)				DFS HR
		L	R	Rectum	P value	L	R	Rectum	P value	L	R	Rectum	P value
Wang et al[38]	2018					22.4	29.1
Gasser et al[12]	2019	12.6	9.1	9.6
Marques et al[11]	2018									1	1.1
Russolillo et al[21]	2019	32.7	20.8		0.002a
Connor et al[40]										1	1.6
Eefsen et al[41]										0.60	1	0.92
Schirripa et al[33]	2015					12.0	10.7	12.6		1	1.23	1.04
Amikura et al[32]	2018					35.4	32.3			1.09	1
Yamashita et al[26]	2018					27	15		0.001a	1	1.71		< 0.0001a
						41	21		0.001a	1	1.48		< 0.0001a
Creasy et al[9]	2016					37	29				1.14
Sasaki et al[23]	2016					20.2	28		0.001a
Heise et al[22]	2017									0.19	1		0.001a
Shigematsu et al[44]	2018									0.85	1	0.97
Wang et al[46]	2017									1.36	1
Berardi et al[47]	2018									1.06	1	1.63
Cremolini et al[16]	2018									0.81	1
Imai et al[35]	2019	22.9	21.3
Liao et al[10]	2018					70.9	66.5		0.033a

Yamashita et al[26]: Data for study set above data for validation set, midgut vs hindgut, not left vs right; Imai et al[35]: 5 Year DFS% not 3-year disease free survival.

^aP < 0.05. DFS: Disease free survival; L: Left; R: Right; HR: Hazard ratio.