Impact of primary tumour location on colorectal liver metastases: A systematic review

Table 2 Overall survival data

Ref.	Year	Median OS (mo)				5 Year OS (%)				OS Hazard ratio
		L	R	Rectum	P value	L	R	Rectum	P value	L	R	Rectum	P value
Zhou et al[27]	2017	35	33	32		27.5	23.1	23		0.85	1	1.02
Zhang et al[30]	2017	22	12		0.012a
		14	10
Makowiec et al[37]	2018					41	46
Chafai et al[29]	2005					22.5	9.9		< 0.001a	1	1.68		< 0.001a
Rougier et al[15]	1995	8.2	4.5	7.6	< 0.001a
		6.8	3.8	6.6	< 0.001a
Wang et al[38]	2018					38.3	46.5			1	1.08
Gu et al[28]	2018	40.3	29.4		0.042a					1	6.2		< 0.001a
Gasser et al[12]	2019	55.5	33.5	58.2						1	1.53		0.029a
de Haas et al[24]	2010					54	36	48	0.001a	1	1.5
Marques et al[11]	2018									1	2.1
Russolillo et al[21]	2019	63.3	35.7		0.002a					0.82	1		< 0.001a
Umeda et al[34]	2013									1.24	1	1.62
Zheng et al[31]	2018	29.5	21.9		< 0.001a					0.5	1		< 0.001a
Mavros et al[39]	2013									1	1.09
Viganò et al[20]	2014	41.3	58.3	47.4		43.1	44.7	41.3
Connor et al[40]	2016									1	2.4		0.0321a
Eefsen et al[41]	2015									0.63	1	0.57	0.045a
Schirripa et al[33]	2015	57.3	35.5	61.1	0.017a					1	1.59	0.95	0.017a
Loosen et al[42]	2018									1	2.32
Amikura et al[32]	2018					56.1	48.4			1	1.287
Yamashita et al[26]	2018					52	32		< 0.0001a	1	2.04		< 0.0001a
						78	55		0.003a	1	1.9		0.0009a
Dulundu et al[19]	2017	30.43	46.38	40.86		52.5	54.1	59
Creasy et al[9]	2016	62.4	43.2			50.4	38.5		0.028a	1	1.22		0.028a
Sasaki et al[23]	2016	55.3	44.1		0.033a	53.7	41.5			0.76	1		0.033a
Palkovics et al[43]	2018	39	36	40
Dupré et al[8]	2018	45.3	34.6		0.035a	37.5	25.4		0.010a	1	1.429		0.036a
Shigematsu et al[44]	2018									0.67	1	0.63
Rhu et al[45]	2017									0.862	1
Wang et al[46]	2017									0.75	1
Norén et al[18]	2015	61	57	48	0.02a	45.8	44.5	42.6	0.02a	0.75	1	0.73	< 0.001a
Cremolini et al[16]	2018									0.96	1
McCracken et al[48]	2019	75.6	54		< 0.001a					1	1.6		0.001a
McVey et al[49]	2019	43	44.2							1.108	1
		79.4	64.6		0.037a					0.629	0.788		0.024a
Imai et al[35]	2019					55.5	52.3			1	3.44		0.021a
Koch et al[36]	2018									0.66	1
Liao et al[10]	2018					75.2	61.7		0.005a
Adam et al[50]	2011					31	0	36	0.003a	1	2.2		0.003a
Wang et al[17]	2019					40.1	24.6		< 0.001a	1	1.75		< 0.001a

Zhang et al[30]: Top group: Overall population, bottom row: Patients who did not receive chemotherapy; Rougier et al[15]: Resection subgroup data presented in row above non-resection subgroup data; Yamashita et al[26]: Data for study set displayed above data for validation set; McVey et al[49]: R1 Resection data displayed over R0 Resection data. OS: Overall Survival.

^aP < 0.05. L: Left; R: Right.