Predictive indicators of successful tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia

Table 2 Inclusion and exclusion criteria for patient selection from the Canarian-chronic myeloid leukemia “Tyrosine kinase inhibitor treatment discontinuation in patients with chronic-phase chronic myeloid leukemia” protocol

Inclusion criteria, all should be met	Exclusion criteria
Aged 18 yr or over, with diagnosis of CML in chronic phase	Resistance to any TKI or insufficient response to imatinib
Received 5 yr or more of TKI treatment (imatinib, bosutinib, nilotinib or dasatinib)	Accelerated phase or blastic crisis in any moment
Maintained a MR4.5 (BCR-ABL1/ABL1 < 0.0032%) or better in all samples taken during the last 3 yr (with at least one recent sample certified in a centralized laboratory)	Detection of BCR-ABL1 kinase domain mutations in any moment
Present a typical BCR-ABL1 transcript at diagnosis that permits quantifiable molecular monitoring
A low or intermediate Sokal index at diagnosis
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CML: Chronic myeloid leukemia; MR: Molecular response; TKI: Tyrosine kinase inhibitor.