Overall and cause-specific survival for mucoepidermoid carcinoma of the major salivary glands: Analysis of 2210 patients

Table 2 Cause-specific survival analysis of mucoepidermoid carcinoma of the major salivary glands

	n	Median survival	Univariate hazard ratio		Multivariate hazard ratio
		95%CI	Estimate	95%CI	Estimate	95%CI
Age bands
00-09	11	Cannot estimate	Cannot estimate		Cannot estimate
10-19	86	Cannot estimate	0.23b	0.03-0.90	0.28b	0.10-0.74
20-29	174	Cannot estimate	0.23b	0.06-0.67	0.29c	0.16--0.51
30-39	275	Cannot estimate	0.71	0.37-1.34	0.95	0.85-1.06
40-49	319	Cannot estimate	Reference		Reference
50-59	431	Cannot estimate	2.50a	1.62-3.96	1.99c	1.30-3.06
60-69	381	Cannot estimate	3.34a	2.17-5.29	2.47c	2.18-2.80
70-79	336	Cannot estimate	5.41a	3.48-8.67	3.00c	2.63-3.43
80+	197	Cannot estimate	7.67a	4.69-12.92	3.47c	3.17-3.79
Stage
Localized	1344	Cannot estimate	Reference
Regional	591	Cannot estimate	7.46a	5.78-9.70	3.90c	3.77-4.04
Distant	143	41 ± 23.43	16.71a	11.95-23.34	5.79c	5.77-5.81
Unknown	132	Cannot estimate	6.27a	3.62-10.38	3.01c	1.79-5.05
Primary tumor size (mm)
0-10	209	Cannot estimate	Reference		Reference
11-20	576	Cannot estimate	1.87	0.86-4.62	1.4b	1.01-1.92
21-30	355	Cannot estimate	5.08a	2.41-12.34	2.13c	1.48-3.06
31-40	150	Cannot estimate	8.18a	3.75-20.31	2.27b	1.04-4.95
41-50	57	Cannot estimate	17.24a	7.48-44-63	3.19c	2.44-4.17
> 50	87	89 ± 108.69	18.24a	8.30-45.63	3.53c	2.58-4.83
Unknown/unspecific	776	Cannot estimate	6.25a	3.10-14.69	2.57c	1.73-3.82
Grade
I	403	Cannot estimate	Reference		Reference
II	850	Cannot estimate	1.75	0.98-3.33	1.56	0.88-2.76
III/IV	538	Cannot estimate	15.48a	9.17-28.16	4.35c	2.52-7.52
Unknown	419	Cannot estimate	7.02a	4.06-13.01	2.92c	1.67-5.10
Race
American Indian/Alaska Native	16	Cannot estimate	1.24	0.33-3.20	4.29c	2.18-8.48
Asian or Pacific Islander	206	Cannot estimate	0.64b	0.41-0.96	0.79	0.52-1.19
Black	239	Cannot estimate	0.66b	0.44-0.95	1.06	0.94-1.19
Unknown	23	Cannot estimate	0.00b	0.00-0.90	Cannot estimate
White	1726	Cannot estimate	Reference		Reference
Sex
Female	1093	Cannot estimate	Reference		Reference
Male	1117	Cannot estimate	2.38a	1.92-2.96	1.36b	1.09-1.69
Radiation
No/unknown	1200	Cannot estimate	0.27a	0.22-0.34	2.10	0.43-1.49
Yes	1010	Cannot estimate	Reference		Reference
Sequence
Not applicable	1260	Cannot estimate	Reference		Reference
Radiation after surgery	902	Cannot estimate	2.66a	2.15-3.30	0.96	0.50-1.84
Radiation before surgery	48	Cannot estimate	2.79c	1.55-4.70	1.05	0.47-2.33
Surgery
No	77	Cannot estimate	4.37a	2.89-6.38	2.17b	1.18-3.98
Unknown	28	74 ± 7.67	4.84a	2.54-8.44	1.62c	1.49-1.76
Yes	2105	Cannot estimate	Reference		Reference
Diagnosis year
1975-1995	960	Cannot estimate	1.40b	1.14-1.73	1.33b	1.03-1.72
1996-2016	1250	Cannot estimate	Reference		Reference
Surgery type					Variable not used in multivariate analysis
Excision	2085	Cannot estimate	Reference
Limited surgical procedure/biopsy	20	Cannot estimate	1.50	0.48-3.55
None	77	Cannot estimate	4.41a	2.92-6.44
Unknown	28	74 ± 7.67	4.89a	2.57-8.53
Diagnosis year					Variable not used in multivariate analysis
1975-1984	405	Cannot estimate	2.09a	1.53-2.88
1985-1994	497	Cannot estimate	1.47b	1.06-2.04
1995-2004	564	Cannot estimate	1.44b	1.05-1.98
2005-2016	744	Cannot estimate	Reference

^aP < 0.0001.

^bP < 0.05.

^cP < 0.001.