Overall and cause-specific survival for mucoepidermoid carcinoma of the major salivary glands: Analysis of 2210 patients

Table 1 Overall survival analysis of mucoepidermoid carcinoma of the major salivary glands

	n	Median survival	Univariate hazard ratio		Multivariate hazard ratio
		95%CI	Estimate	95%CI	Estimate	95%CI
Age bands
00-09	11	Cannot estimate	Cannot estimate		Cannot estimate
10-19	86	Cannot estimate	0.12a	0.02-0.37	0.13c	0.06-0.32
20-29	174	Cannot estimate	0.16a	0.07-0.32	0.18c	0.12-0.26
30-39	275	Cannot estimate	0.62b	0.42-0.92	0.73c	0.68-0.78
40-49	319	401 ± 38.42	Reference		Reference
50-59	431	248 ± 13.93	2.55a	1.93-3.39	2.51c	2.33-2.69
60-69	381	167 ± 26.25	5.00a	3.75-6.75	4.31c	3.28-5.67
70-79	336	70 ± 17.94	11.38a	8.25-15.95	7.52c	6.91-8.18
80+	197	35 ± 6.87	20.02a	13.67-29.92	12.24c	11.58-12.95
Stage
Localized	1344	342 ± 26.24	Reference		Reference
Regional	591	99 ± 19.59	3.07a	2.66-3.54	1.95c	1.95-1.96
Distant	143	29 ± 9.64	6.96a	5.51-8.75	2.84c	2.73-2.95
Unknown	132	118 ± 61.69	2.69a	1.86-3.80	1.6b	1.11-2.31
Primary tumor size (mm)
0-10	209	Cannot estimate	Reference		Reference
11-20	576	331 ± 59.73	1.95c	1.30-3.01	1.64c	1.39-1.94
21-30	355	248 ± 54.66	3.15a	2.08-4.91	2.07c	1.36-3.13
31-40	150	141 ± 57.38	4.63a	2.97-7.40	2.23c	1.98-2.52
41-50	57	46 ± 38.76	9.26a	5.56-15.59	2.66c	1.52-2.81
> 50	87	52 ± 36.21	9.14a	5.67-15.05	2.87c	2.63-3.13
Unknown/unspecific	776	220 ± 26.3	3.43a	2.35-5.18	2.09c	1.73-2.51
Grade
I	403	401 ± 48.25	Reference		Reference
II	850	340 ± 33.68	1.26	0.98-1.63	1.30b	1.02-1.67
III/IV	538	55 ± 11.05	5.44a	4.27-6.99	2.10c	1.98-2.23
Unknown	419	201 ± 39.44	2.49a	1.94-3.20	1.61c	1.52-1.70
Race
American Indian/Alaska Native	16	Cannot estimate	0.47	0.13-1.20	1.64	0.61-4.45
Asian or Pacific Islander	206	308 ± 66.3	0.70b	0.53-0.91	0.93	0.71-1.21
Black	239	Cannot estimate	0.59a	0.45-0.76	1.00	0.78-1.29
Unknown	23	Cannot estimate	0.10c	0.00-0.54	0.31	0.04-2.26
White	1726	226 ± 21.22	Reference		Reference
Sex
Female	1093	327 ± 31.14	Reference		Reference
Male	1117	187 ± 22.69	1.76a	1.54-2.01	1.26b	1.10-1.44
Radiation
No/unknown	1200	340 ± 34.89	0.46a	0.40-0.53	1.07	0.70-1.63
Yes	1010	147 ± 23.39	Reference		Reference
Sequence
Not applicable	1260	327 ± 29.07	Reference		Reference
Radiation after surgery	902	162 ± 25.62	1.82a	1.59-2.08	1.18	0.76-1.83
Radiation before surgery	48	162 ± 56.48	1.67b	1.12-2.40	1.17c	1.10-1.25
Surgery
No	77	27 ± 11.81	4.26a	3.16-5.64	2.09c	1.40-3.10
Unknown	28	16 ± 10.37	4.43a	2.87-6.57	2.41c	1.43-4.05
Yes	2105	263 ± 23.24	Reference		Reference
Diagnosis year
1975-1995	960	221 ± 23.77	1.31c	1.13-1.52	1.38c	1.16-1.64
1996-2016	1250	Cannot estimate	Reference		Reference
Surgery type
Excision	2085	261 ± 23.23	Reference		Variable not used in multivariate analysis
Limited surgical procedure/biopsy	20	Cannot estimate	1.01	0.52-1.96
None	77	27 ± 11.81	4.28a	3.17-5.67
Unknown	28	16 ± 10.37	4.44a	2.88-6.59
Diagnosis year
1975-1984	405	207 ± 31.31	1.77a	1.39-2.26	Variable not used in multivariate analysis
1985-1994	497	230 ± 36.99	1.50c	1.18-1.91
1995-2004	564	Cannot estimate	1.32b	1.04-1.68
2005-2016	744	Cannot estimate	Reference

^aP < 0.0001.

^bP < 0.05.

^cP < 0.001.